From Convergence to Compromise: Understanding the Interplay of Digital Transformation and Mergers on Data Breach Risks in Local and Cross-Border Mergers

In today\u27s digital age, the potential risks and challenges associated with digital transformation (DT) and cybersecurity have received limited research attention. This dissertation consists of three interconnected studies that aim to address this gap. The first study employs paradox theory to demonstrate that DT initiatives can increase a firm\u27s susceptibility to data breaches. Using a unique dataset spanning 10 years and involving 3604 brands, our analysis reveals that DT efforts in mobile and digital marketing are associated with a higher incidence of data breaches. However, firms can mitigate this impact by enhancing their innovative capacities. These findings contribute to a better understanding of the complex relationship between DT, data breaches, and innovation. Our second investigation, rooted in complexity theory and matching theory, examines the impact of mergers and acquisitions (M&As) on the frequency of data breaches. By analyzing 18 years of data from 5072 US firms, we find that M&As increase the likelihood of data breaches, particularly when the merging firms operate in different business domains. Furthermore, we observe that M&As that receive more media attention are more prone to data breaches, while those involving a more vulnerable target firm have fewer breaches. In our third study, guided by Institutional theory, we explore the relationship between cross-border mergers and acquisitions (CBMA) and data breaches. Our findings indicate that CBMAs, especially those accompanied by significant media publicity and involving firms from divergent institutional contexts, heighten the risk of data breaches. Overall, these studies provide valuable insights for firms aiming to mitigate data breach risks during their digital transformation (DT) efforts and M&A activities. They emphasize the importance of adopting a balanced communication strategy and considering the security implications of strategic actions. Moreover, our findings contribute to the academic discourse in information systems by illuminating the intricate interplay between DT, M&As, and data breaches

Role of isoflavones and its derivatives on the growth of Pseudomonas putida and Escherichia coli

Two naturally occurring isoflavones genistine and biochanin - A, and their dihydro derivatives (isoflavones) as well as nine perhydroginated isoflavones (isoflavanes) were tested for their effects on mycelial growth of two soil bacteria viz., Pseudomonas putida and Escherichia coli. All the isoflavonenoids of the biochanin - A series showed the genistine isoflavane and the other isoflavanes with two hydroxyl groups and one methoxy groups are toxic, while isoflavones with two and one methoxy group were almost inactive. Genistein, a radio protective soy isoflavone and protein kinase inhibitor, blocks the invasion of pathogenic bacteria in mammalian epithelial cells. The purpose of this study was to evaluate the direct effect of genistein on the survival and growth of the probiotic Lactobacillus reuteri and selected opportunistic bacteria in vitro as a prelude to in vivo use for managing post irradiation sepsis. The opportunistic bacterial enteropathogens viz., Escherichia coli, Shigella sonnei, and Staphylococcus aureus as well as Klebsiella pneumoniae and the non-pathogenic organism, Bacillus anthracis (Sterne) were evaluated. The latter two bacteria are found in the environment and may be of concern in irradiated individuals. A standard in vitro test was employed to evaluate the direct effect of genistein on the bacteria

Evaluation of efficacy of Carica papaya leaf extracts to increase platelet count in hydroxyurea induced thrombocytopenia in Albino rats

Background: Dengue is an infectious disease associated with high mortality and morbidity. Being a viral disease, there is no specific drug available for treatment. There are some reports that Carica papaya leaf extract may improve the clinical condition of dengue patients. However, to support this, at present, there is no systematically searched and synthesized evidence available. Hence this study was undertaken to compare the efficacy of commercial preparation of Carica papaya leaves with freshly prepared Carica papaya leaf extracted.Methods: 48 albino rats were randomly divided into eight groups of six each. Thrombocytopenia was induced by giving hydroxyurea (15mg/kg) orally. Group I and II served as saline and toxic control group respectively. Other six groups were given two different doses of either commercial extract or fresh extract orally for five days. 1ml of blood was withdrawn at baseline,3rd and 6th day of the study. Platelet, WBC, RBC count, clotting and bleeding time were determined.Results: Mean platelet count increased significantly on day 6 in both low dose (2.06 to 4.93lakh/mm3) and human equivalent dose (2.73 to 7.66lakh/mm3) of commercial extract groups compared to the toxic control group (p<0.05). Similarly, the mean platelet count increased significantly for human equivalent dose in fresh leaf extract group (3.17 to 4.69lakh/mm3) but the increase in low dose fresh extract (3.28 to 3.76lakh/mm3) was not significant. There was no significant rise in mean platelets count, mean RBC count, WBC count, decrease in mean bleeding and clotting time between commercial extract and fresh leaf extract group for both low dose and human equivalent dose.Conclusions: Efficacy of fresh leaf extract of Carica papaya was not inferior to commercial available preparation. Fresh Carica papaya leaf extract no doubt offers a potential therapeutic efficacy which is cost effective, more affordable and accessible treatment in patients with thrombocytopenia

A study on the prevalence of obesity and metabolic syndrome among students of a medical college

Background: Obesity is emerging as a serious problem throughout the world. The overall life expectancy is significantly shortened and the quality of life decreased in those who are excessively overweight. Metabolic syndrome (MetS) is characterized by a constellation of individual risk factors of cardiovascular disease. Central obesity is a key feature of this syndrome, reflecting the fact that the syndrome’s prevalence is driven by strong relationship between waist circumference and increasing obesity. Awareness about MetS in medical students is the need of the hour.Methods: This cross-sectional study was conducted at Dr. PSIMS and RF, Chinnoutpalli, Andhra Pradesh, India involving 400 medical students. A pre-tested questionnaire, measurement of blood pressure, fasting glucose level, fasting lipid profile, anthropometric variables such as height, weight, waist circumference and hip circumference were taken. Metabolic syndrome was defined based on the International Diabetes Federation criteria. Data was processed using SPSS version 16. T-test, chi-square test, fisher’s exact test, anova and odd’s ratio were used for statistical analysis.Results: 59% of the study population was female. The prevalence of obesity was 4%, with majority being males (81.25%) The MetS prevalence as per the International diabetes federation (IDF) criteria was 6% (n=24). The prevalence of MetS in males was 12.19% (n=20) and in females 1.69%. (n=4). The risk of developing metabolic syndrome is high among those who smoke, consume alcohol, consume junk food and sleep for longer durations.Conclusions: The prevalence of metabolic syndrome is 6%. A significant association is established between life style habits like smoking, alcohol consumption, junk food consumption, sleep duration and MetS

The Prevalence of Bilateral Three-Rooted Mandibular First Molar in Indian Population

Introduction: The purpose of the present study was to evaluate the prevalence of bilateral three-rooted mandibular first and second molars in Indian population. Materials and Methods: A total of 215 patients were screened bilaterally for mandibular first and second molar and 430 samples of periapical radiographs were obtained. The gender, symmetry, and prevalence of three-rooted mandibular first and second molars were recorded. The correlation between left and right side occurrences and distribution were recorded and analysed using Z-test. Results: The results showed that 33 teeth had three-rooted mandibular first molars, 16 male and 17 female (P=0.442). Overall, 21 teeth of right jaw and 12 teeth of left jaw (P=0.103) showed presence of an extra-root. The prevalence of three-rooted mandibular first molars was 7.67% and second molar was 0.23%. The bilateral frequency distribution was 3.72% for the first molar. There was no statistically significant difference between right side and left side mandibular molars. Also, gender did not show a significant relationship with this variant. Conclusion: The endodontic treatments of first mandibular molars require a careful clinical approach in Indian population as a high racial prevalence of 7.67% three-rooted molars was found. However, in the same population, 0.23% mandibular second molars had three roots

Garlic ameliorates long-term pre-diabetes induced retinal abnormalities in high fructose fed rat model

452-460Retinopathy is one of the micro vascular complications of diabetes and can also be observed in pre-diabetic state. However, there are only limited studies available on the pathophysiology of retinopathy in pre-diabetic state and its preventive strategies. In this study, we investigated the retinal functional, structural and molecular alterations using high fructose (HF) induced pre-diabetic rat model and also the protective role of garlic. Feeding of HF to Wistar NIN (WNIN) rats had developed insulin resistance (IR) and impaired glucose tolerance (IGT) by three months, while retinal functional abnormalities by ten months as evidenced by decrease of Electroretinogram (ERG) scotopic, photopic b-wave amplitudes, oscillatory potentials (OPs) when compared to controls. Supplementation of garlic (3%) to HF+G group rats had marginally protected these changes. Elevated expression of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), aldose reductase (AR) and decreased rhodopsin (Rho) in HF group rats as evidenced by immunehistochemistry, immunoblot methods, which were further supported by gene expression studies, indicate the initiation of retinal abnormalities. Increased immune-fluorescence signal of carboxymethyl lysine (CML-KLH) and 4-hydroxynanoenol (4-HNE) in retina of HF group rats indicate the association of glycation and oxidative stress, respectively. Early intervention of garlic to HF+G group rats attenuated retinal functional, structural, and molecular abnormalities

Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS

Studies on ligand interaction with quadruplex DNA, and their role in stabilizing the complex at concentration prevailing under physiological condition, has attained high interest. Electrospray ionization mass spectrometry (ESI-MS) and spectroscopic studies in solution were used to evaluate the interaction of PBD and TMPyP4 ligands, stoichiometry and selectivity to G-quadruplex DNA. Two synthetic ligands from PBD family, namely pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrid (PBD1), mixed imine-amide pyrrolobenzodiazepine dimer (PBD2) and 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4) were studied. G-rich single-stranded oligonucleotide d(5′GGGGTTGGGG3′) designated as d(T2G8), from the telomeric region of Tetrahymena Glaucoma, was considered for the interaction with ligands. ESI-MS and spectroscopic methods viz., circular dichroism (CD), UV-Visible, and fluorescence were employed to investigate the G-quadruplex structures formed by d(T2G8) sequence and its interaction with PBD and TMPyP4 ligands. From ESI-MS spectra, it is evident that the majority of quadruplexes exist as d(T2G8)2 and d(T2G8)4 forms possessing two to ten cations in the centre, thereby stabilizing the complex. CD band of PBD1 and PBD2 showed hypo and hyperchromicity, on interaction with quadruplex DNA, indicating unfolding and stabilization of quadruplex DNA complex, respectively. UV-Visible and fluorescence experiments suggest that PBD1 bind externally where as PBD2 intercalate moderately and bind externally to G-quadruplex DNA. Further, melting experiments using SYBR Green indicate that PBD1 unfolds and PBD2 stabilizes the G-quadruplex complex. ITC experiments using d(T2G8) quadruplex with PBD ligands reveal that PBD1 and PBD2 prefer external/loop binding and external/intercalative binding to quadruplex DNA, respectively. From experimental results it is clear that the interaction of PBD2 and TMPyP4 impart higher stability to the quadruplex complex

Microleakage evaluation of Silorane-based composite and Methacrylate-based composite in class II box preparations using two different layering techniques: An in vitro study

Aim: The aim of this study was to compare the microleakage in Class II box preparations with the gingival margin above and below the cemento-enamel junction (CEJ) restored with Silorane composite and methacrylate composite using two different layering techniques. Materials and Methods: Standardized box preparations (mesial box 1 mm above the CEJ and distal box 1 mm below the CEJ) were prepared in 60 upper premolars. The teeth were randomly divided into four groups containing 15 samples each; Group I: Restored with a Silorane composite using an oblique layering technique, Group II: Restored with Silorane composite using a vertical layering technique, Group III: Restored with methacrylate composite using the oblique layering technique, and Group IV: Restored with methacrylate composite using the vertical layering technique. The samples were stored in distilled water, followed by thermocycling and immersed in 2% methylene blue. The samples were sectioned and evaluated for microleakage at the gingival margin. Statistical Analysis: Kruskal-Wallis, Fischer exact test, Wilicoxon test, and Mann-Whitney U test. Results: Silorane composite had significantly lesser microleakage. No significant difference in microleakage was observed above and below the CEJ for Silorane-based composite. Conclusion: Silorane composite resin showed lesser microleakage compared to methacrylate composite resin. Clinical Significance: The Silorane-based composites improve the marginal adaptation due to their reduced shrinkage, thereby decreasing the residual stress at the adhesive-tooth interface